Publications

Pre-prints

Smalec BM*, Ietswaart R*, Choquet K, McShane E, West ER, Churchman LS. (2022) Genome-wide quantification of RNA flow across subcellular compartments reveals determinants of the mammalian transcript life cycle. bioRxiv. p. 2022.08.21.504696.

Selected publications since 2015

Choquet K, Koenigs A, Dülk SL, Smalec BM, Rouskin S, Churchman LS. (2022) Pre-mRNA splicing order is predetermined and maintains splicing fidelity across multi-intronic transcripts. Nat Struct Mol Biol 30, 1064-1076.

McShane E, Couvillion M, Ietswaart R, Prakash G, Smalec BM, Soto I, Baxter-Koenigs AR, Choquet K, Churchman LS. (2024) A kinetic dichotomy between mitochondrial and nuclear gene expression processes. Mol Cell 84, 1541-1555.

Kramer NJ, Prakash G, Isaac RS, Choquet K, Soto I, Petrova B, Merens HE, Kanarek N, Churchman LS. (2023) Regulators of mitonuclear balance link mitochondrial metabolism to mtDNA expression. Nat Cell Biol, online ahead of print.

Martell DJ, Merens HE, Fiorini C, Caulier A, Ulirsch J, Ietswaart R, Choquet K, Graziadei G, Brancaleoni V, Cappellini MD, Scott C, Roberts N, Proven M, Roy NBA, Babbs C, Higgs DR, Sankaran VG, Churchman LS. (2023) RNA Polymerase II pausing temporally coordinates cell cycle progression and erythroid differentiation. Dev Cell, online ahead of print.

Lata E*, Choquet K*, Sagliocco F, Brais B, Bernard G, Teichmann M. (2021) RNA Polymerase III Subunit Mutations in Genetic Diseases. Front Mol Biosci 8, 696438.

Drexler HL*, Choquet K*, Merens HE, Tang PS, Simpson JT, Churchman LS. (2021) Revealing nascent RNA processing dynamics with nano-COP. Nat Protocols 16, 1343-1375.

Drexler HL, Choquet K, Churchman LS.  (2020) Splicing kinetics and coordination revealed by direct nascent RNA sequencing through nanopores. Mol Cell 77, 985-998.

Choquet K, Forget D, Meloche E, Dicaire MJ, Bernard G, Vanderver A, Schiffmann R, Fabian MR, Teichmann M, Coulombe B, Brais B, Kleinman CL. (2019) Global reduction of tRNA levels and the brain cytoplasmic BC200 RNA in cellular models of POLR3-related leukodystrophy. J Biol Chem 294, 7445-7459.

Choquet K, Pinard M, Yang S, Moir RD, Poitras C, Dicaire MJ, Sgarioto N, Larivière R, Kleinman CL, Willis IM, Gauthier MS, Coulombe B, Brais B. (2019) The leukodystrophy mutation Polr3b R103H causes homozygote mouse embryonic lethality and impairs RNA polymerase III biogenesis. Molecular Brain 12, 59.

Larivière R, Sgarioto N, Marquez BT, Gaudet R, Choquet K, McKinney RA, Watt AJ, Brais B. (2019) Sacs R272C missense homozygous mice develop an ataxia phenotype. Molecular Brain 12, 19.

Darbelli L*, Choquet K*, Richard S, Kleinman CL. (2017) Transcriptome profiling of mouse brains with qkI-deficient oligodendrocytes reveals major alternative splicing defects including self-splicing. Scientific Reports 7, 7554.

Choquet K, Yang S, Moir RD, Forget D, Bouchard A, Lariviere R, Sgarioto N, Dicaire MJ, Noohi F, Kennedy TE, Rochford J, Bernard G, Teichmann M, Coulombe B, Willis IM, Kleinman CL, Brais B. (2017) Absence of neurological abnormalities in mice homozygous for the Polr3a G672E hypomyelinating leukodystrophy mutation. Molecular Brain 10, 13.

Antonicka H, Choquet K, Lin ZY, Gingras AC, Kleinman CL, Shoubridge EA. (2016) A pseudouridine synthase module is essential for mitochondrial protein synthesis and cell viability. EMBO Reports 18, 28-38.

Choquet K, Zurita-Rendon O, La Piana R, Yang S, Dicaire MJ, Care4Rare Consortium, Boycott KM, Majewski J, Shoubridge EA, Brais B, Tétreault M. (2016) Autosomal recessive cerebellar ataxia caused by a homozygous mutation in PMPCA. Brain 139, e19.

Choquet K*, Tetreault M*, Yang S, La Piana R, Dicaire MJ, Vanstone MR, Mathieu J, Bouchard JP, Rioux MF, Rouleau GA, Care4Rare Canada Consortium, Boycott KM, Majewski J, Brais B. (2015) SPG7 mutations explain a significant proportion of French Canadian spastic ataxia cases. Eur J Hum Genet 24, 1016-1021.